David Shin-Hsiung Tang

This study identifies mosaic chromosomal alterations in healthy human tissues, revealing tissue-specific patterns of mitotic errors and purifying selection across aging.

This study identifies genetic factors influencing mosaic aneuploidies in blood genomes using whole-genome sequencing data from 840,853 individuals.

The paper identifies 43,617 mosaic chromosomal alterations in blood from 484,081 UK Biobank participants, revealing genomic hotspots and associations with age-related clonal expansions and genetic pathways.

The paper examines how human genetic and environmental factors influence viral DNA load in blood and saliva, identifying genetic loci and alleles associated with specific viruses and their health impacts.

The paper analyzes DNA repeat instability in 700,000 participants to identify genetic modifiers of repeat expansion and contraction rates and their clinical associations.

This paper introduces EFA, a model that factorizes polygenic epistasis to improve prediction and uncover biological pathways in complex traits.