Paul Wirsching

The paper proposes the amygdala burnout hypothesis, showing early-life stress leads to initial amygdala volume increases in adolescence followed by reductions in older age across rodents and humans.

The paper examines how childhood adversity dimensions relate to frontostriatal network connectivity and anhedonia in young adults, finding sex-specific associations.

The paper uses longitudinal fMRI data to show that proactive and reactive control networks stabilize after mid-adolescence, predicting cognitive stability and psychopathology.

This study examines how different types of adversity affect grey and white matter development in adolescents across two cohorts, finding distinct associations between adversity types and brain structure metrics.

The paper uses longitudinal neuroimaging and behavioural data to show how brain-behaviour relationships shift from externalising to internalising symptoms across adolescence, identifying age 14 as a critical transition point.

The paper develops a digital twin brain model that simulates and manipulates functional brain networks to predict mental illness symptoms and responses to interventions.

This study shows that lrrk2 knockout in zebrafish causes dopamine and serotonin catabolism changes, reduced cell proliferation, and impaired neuronal regeneration.