Linhui Xie

The paper benchmarks generative methods for designing peptides in TCR-pMHC complexes, revealing method-dependent differences in backbone generation and conformational diversity.

This study investigates how Alzheimer's risk SNPs affect chromatin functions and how their genomic context influences these effects.

The paper introduces MoFNet, a deep neural network that integrates multi-omic data to identify functional subnetworks associated with Alzheimer's Disease, showing replication in an independent cohort.

This study identifies genetic influences on brain connectivity across age groups using GWAS and finds a consistent effect of rs7937515 on network segregation in the left middle temporal gyrus.

The paper identifies a functionally connected subnetwork of 276 multi-omic biomarkers for Alzheimer’s Disease using a modularity-constrained Lasso model applied to the ROS/MAP cohort.