Author

Xiaotong Shen

University of MinnesotaORCID 0000-0003-1300-1451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Wei PaniD· 3 shared Ben DaiiD· 1 shared Binghui LiuiD· 1 shared Chong WuiD· 1 shared Chunlin LiiD· 1 shared Mykhaylo M. MalakhoviD· 1 shared Rachel Zilinskas· 1 shared Tianzhong YangiD· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 12 mutual co-author links

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3 shared papersBioinformatics

Wei PanORCID

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3 papers

Recent·Most cited

BioinformaticsThe Annals of Applied StatisticsPeer-reviewedAug 6, 2024

A bootstrap model comparison test for identifying genes with context-specific patterns of genetic regulation

Mykhaylo M. Malakhov, Ben Dai, Xiaotong Shen, Wei Pan

DRAB identifies genes with context-specific genetic regulation by comparing models across tissues using bootstrapping and elastic net.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologyBiometricsPeer-reviewedJan 29, 2024

Inferring a directed acyclic graph of phenotypes from GWAS summary statistics

Rachel Zilinskas, Chunlin Li, Xiaotong Shen…·Tianzhong Yang

The paper infers a directed acyclic graph of phenotypes from GWAS summary statistics and applies it to cardiovascular proteins linked to Alzheimer's disease.

5 citations

GWAS summary statisticsstatistical model

𝕏 PostBluesky

BioinformaticsThe Annals of Applied StatisticsPeer-reviewedSep 1, 2017

A Novel And Efficient Algorithm For De Novo Discovery Of Mutated Driver Pathways In Cancer

Binghui Liu, Chong Wu, Xiaotong Shen, Wei Pan

The paper introduces a new algorithm for de novo discovery of mutated driver pathways in cancer, showing improved efficiency and scalability over existing methods.

11 citations

humanwhole-exome sequencing

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