Daniel M. Weinreich

The paper introduces SME, a fast method for detecting genome-wide epistasis in large biobank studies by focusing on functionally relevant genomic regions.

This paper develops a theoretical framework to study the evolution of heritable biological noise, showing how natural selection shapes the amount of noise in organisms.

This study examines cleistogamy as a bet hedging strategy by analyzing biogeographic patterns across 400 species, finding it more common in cooler, variable environments.

This paper introduces mvMAPIT, a method to detect epistasis in GWAS by jointly modeling multiple traits, showing improved power over single-trait approaches.

The paper identifies two mutations in TEM beta-lactamase that shift drug specificity through salt bridges, validated by simulations and experiments.