NeuroscienceNature Chemical BiologyPeer-reviewed
ADP-ribose triggers neuronal ferroptosis by rewiring purine and pyrimidine metabolism
Haoqi Ni, Yingying He, Qiao Ye…·Lin Yuan
This study identifies ADP-ribose as a mediator of neuronal ferroptosis through metabolic rewiring, showing that blocking its signaling alleviates cognitive decline in mouse models.
DOI 10.1038/s41589-026-02355-2