Author

Siying Chen

Columbia UniversityORCID 0000-0003-1534-6525Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Dana Wintner· 1 shared Elise D. FlynniD· 1 shared Shuang Wu· 1 shared Xinwei HaniD· 1 shared Yufeng SheniD· 1 shared

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2018-2018 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperGenomics

Dana Wintner

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1 paper

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedMay 24, 2018

Distinct Epigenomic Patterns Are Associated with Haploinsufficiency and Predict Risk Genes of Developmental Disorders

Xinwei Han, Siying Chen, Elise D. Flynn…·Yufeng Shen

The paper develops Episcore, a method using epigenomic data to predict haploinsufficient genes, showing improved performance over existing methods in prioritizing loss of function variants in developmental disorders.

40 citations

humanwhole-exome sequencing

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