Author

Thomas J. Cross

University of California, IrvineORCID 0000-0003-1591-0202Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Organism:virus· 1

Frequent Co-Authors

Carter T. ButtsiD· 1 shared Elizabeth M. DiessneriD· 1 shared Gemma R. TakahashiiD· 1 shared Marquise G. CrosbyiD· 1 shared Rachel W. MartiniD· 1 shared Shannon ZhuangiD· 1 shared Vesta Farahmand· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Carter T. ButtsORCID

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1 paper

Recent·Most cited

Molecular BiologyBiochemistryPeer-reviewedSep 15, 2020

Sequence Characterization and Molecular Modeling of Clinically Relevant Variants of the SARS-CoV-2 Main Protease

Thomas J. Cross, Gemma R. Takahashi, Elizabeth M. Diessner…·Rachel W. Martin

The paper characterizes 79 clinically relevant SARS-CoV-2 main protease variants through sequence analysis, structure prediction, and molecular modeling, revealing patterns in viral evolution and active site flexibility.

46 citations

virusprotein structure

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