Author

Alexander S. Moffett

Northeastern UniversityORCID 0000-0003-1631-2722Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Michele Di PierroiD· 2 shared Andrea Falcón-CortésiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersEvolutionary Biology

Michele Di PierroORCID

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2 papers

Recent·Most cited

Evolutionary BiologyMolecular Biology and EvolutionPeer-reviewedMay 21, 2026

Quantifying the influence of genetic context on duplicated mammalian genes

Alexander S. Moffett, Andrea Falcón-Cortés, Michele Di Pierro

This study quantifies how genetic context influences evolutionary rates in duplicated mammalian genes, finding that target copies in new genomic locations evolve faster than source copies.

3 citations

mousehuman

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintOct 13, 2025

Random, fragile, or correlated: Mechanisms of synteny decay in mammals

Alexander S. Moffett, Michele Di Pierro

The paper evaluates three models of genome evolution by comparing their fit to empirical synteny block size distributions across 200 mammalian genomes, finding that fragile and correlated breakage models better explain synteny decay than the random breakage model.

DOI 10.1101/2025.10.13.682123

mousehuman

𝕏 PostBluesky