Saverio Rossi

This paper introduces a coevolution-aware ancestral sequence reconstruction framework that improves reconstruction by incorporating residue-residue constraints from extant protein families.

This study compares three simulation schemes for modeling protein evolution, finding that population genetics dynamics best capture phylogenetic correlations and selective sweeps without requiring additional data.

The paper quantifies fluctuations in protein evolution by analyzing correlations between mutations and shows ancestral sequence properties influence evolutionary dynamics and reconstruction accuracy.

The paper shows functional bottlenecks can arise from global epistasis with an additive trait, not requiring complex network interactions.