Molecular BiologyIUCrJPeer-reviewed
Exploiting prior knowledge about biological macromolecules in cryo-EM structure determination
Dari Kimanius, Gustav Zickert, Takanori Nakane…·Sjors H. W. Scheres
This paper introduces a regularisation framework for cryo-EM structure determination using a convolutional neural network trained on known macromolecular structures, showing improved reconstructions on simulated data.