Author

Georgina Jiménez Ambriz

Montreal Neurological Institute and HospitalORCID 0000-0003-2496-5993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Sali M.K. FarhaniD· 2 shared Thomas M. DurcaniD· 2 shared Alexandria Schneider· 1 shared Allison Ann DilliottiD· 1 shared Angela Nauleau-Javaudin· 1 shared Anna Kristina Franco-FloresiD· 1 shared Dan SpiegelmaniD· 1 shared Ghazal HaghiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersNeuroscience

Sali M.K. FarhanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeuroscienceBMC Genomic DataPeer-reviewedJul 4, 2026

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson's disease tissue

Indra Roy, Michael Fiorini, Rhalena A. Thomas…·Thomas M. Durcan

This study uses snRNA-seq data from post-mortem Parkinson's disease tissue to identify altered molecular pathways in microglia and astrocytes, showing upregulated protein misfolding responses and downregulated inflammation-related genes.

DOI 10.1186/s12863-026-01462-2

humansnRNA-seq

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NeuroscienceScientific ReportsPeer-reviewedAug 5, 2025

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

Sarah Lépine, Gilles Maussion, Alexandria Schneider…·Thomas M. Durcan

The paper identifies MLN4924 as a compound that improves cell viability in TDP-43 mutant motor neurons by targeting NEDD8-activating enzyme.

5 citations

humanbulk RNA-seq

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