Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924
Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos‐Montiel, Georgina Jiménez Ambriz, Dan Spiegelman, Narges Abdian, Anna Kristina Franco-Flores, Ghazal Haghi, Lale Gursu, Michael R. Fiorini, Allison Ann Dilliott, Sali M.K. Farhan, Mathilde Chaineau, Thomas M. Durcan
The paper identifies MLN4924 as a compound that improves cell viability in TDP-43 mutant motor neurons by targeting NEDD8-activating enzyme.
Scientific Reports · Aug 5, 2025Peer-reviewedNeuroscience