Stacey L. Kigar

This study links transdiagnostic symptom dimensions in healthy females to specific inflammatory profiles using Bayesian regression and PCA, showing associations between social withdrawal and monocyte counts, and anxious-depression with stress-induced inflammation.

Chronic social defeat stress increases meningeal neutrophils via type I interferon signaling from skull bone marrow, contributing to behavioral issues, and blocking this pathway reduces neutrophil trafficking and improves behavior.