GenomicsbioRxivPreprint
T2T-CHM13 vs GRCh38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ethnicity
Junli Nie, Julie Tellier, Ilariya Tarasova…·Gordon K. Smyth
The paper shows that using T2T-CHM13 instead of GRCh38 improves accuracy in identifying immunoglobulin isotypes from scRNA-seq data by matching the genetic background of the samples.