Sandhya Samarasinghe

A novel vaccine and drug targets for global eradication of bovine tuberculosis: Holistic frameworks for construction of a potent vaccine and identification of drug targets

This paper identifies potential vaccine candidates and drug targets for bovine tuberculosis using bioinformatics approaches and proteomic analysis of Mycobacterium bovis strains.

A vaccine for global eradication of TB - A novel conceptual framework and design of a potent peptide-based vaccine with universal coverage through advanced computational vaccinology

This paper proposes a peptide-based TB vaccine using computational vaccinology to identify conserved epitopes across TB strains, aiming for broad-spectrum protection and universal coverage.

Confronting global eradication of TB head on: Uncovering the root of drug resistance and bacterial survival strategies through a comprehensive computational study of first-line TB drug resistant mutations

This study identifies global patterns of drug-resistant mutations in Mycobacterium tuberculosis and reveals a strategy where bacteria prefer less harmful mutations that reduce drug binding affinity while maintaining protein stability.

A Comprehensive Conceptual and Computational Dynamics Framework for Autonomous Regeneration of Form and Function in Biological Organisms

The paper proposes a conceptual and computational framework for regeneration of form and function in biological organisms, demonstrating its ability to restore anatomical and bioelectric homeostasis in an in silico model.

A comprehensive conceptual and computational dynamics framework for Autonomous Regeneration Systems

This paper introduces a computational framework for damage detection and regeneration in multicellular systems, demonstrating its ability to regenerate tissues and stem cells in simulated organisms.