Humam N. Kadara

The paper identifies AP-1 transcription factors as regulators of a transitional state in lung alveolar type 2 cells during injury-repair, linking chromatin changes to both regeneration and tumorigenesis.

This study shows that suppressing SPP1 improves cisplatin sensitivity and inhibits tumor invasion and metastasis in NRF2-hyperactivated cisplatin-resistant HNSCC.

COSIE is a computational framework that integrates multiple spatial omics modalities to generate high-resolution molecular landscapes, outperforming existing methods across diverse datasets.

HistoSweep improves tissue quality control in gigapixel images by removing artifacts and preserving biologically relevant structures, enhancing analysis accuracy in digital pathology and spatial omics.

The paper develops DeMixNB, a deconvolution model for sparse-count RNA sequencing data, showing its utility in analyzing tumor cell plasticity in breast and lung cancer.

TESLA annotates tumor microenvironment cells and detects spatial transcriptome differences using spatial transcriptomics data.

The paper investigates how anti-cancer immunity evolves from preneoplasia to invasive lung adenocarcinomas, identifying changes in immune response and molecular features that may facilitate immune evasion.

This study examines DNA methylation changes and intra-tumor heterogeneity in lung adenocarcinoma progression, finding increased methylation aberrations and immunosuppression in later-stage lesions.

The paper analyzes single-cell RNA-seq data to identify ACE2 expression patterns in human lung epithelial cells, finding high ACE2 expression in alveolar type II cells and co-expression with pathogen receptors.