GeneticsbioRxivPreprint
SeverYX: An ensemble framework for robust variant severity classification
Evyatar Mor, Eldar Dedic, Yaron Mazor…·Lina Zelinger
SeverYX is an ensemble framework that classifies genetic variants into severity tiers, achieving high concordance with ClinVar and improving predictive accuracy through threshold optimization and additional predictors.
DOI 10.64898/2026.11.03.762814