Molecular BiologybioRxivPreprint
Near completely reversing the γ- to β-globin switch by enhancer release, retargeting and reinforcing
Nanyu Wang, Ke Yang, Xuemin Xie…·Depei Liu
This study demonstrates that combined editing of CACCC and TGACCA motifs can nearly reverse the γ- to β-globin switch by redirecting enhancer-promoter interactions.
DOI 10.64898/2026.01.30.702713