Author

Shihe Zhang

Shanghai Jiao Tong UniversityORCID 0000-0003-3151-0882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Han BaoiD· 2 shared Heng XuiD· 2 shared Zhiyang YuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBiophysics

Han BaoORCID

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2 papers

Recent·Most cited

Extrinsic Noise or Intrinsic Coupling: Dissecting Correlated Fluctuations in Gene Transcription

Shihe Zhang, Han Bao, Heng Xu

The paper develops a noise decomposition framework to distinguish intrinsic gene-gene coupling from extrinsic noise in stochastic transcription using single-cell data from Drosophila embryos.

Physical Review Letters · Nov 19, 2025Peer-reviewedBiophysics

Deep Learning-Based High-Resolution Time Inference for Deciphering Dynamic Gene Regulation from Fixed Embryos

Han Bao, Shihe Zhang, Zhiyang Yu, Heng Xu

The paper infers high-resolution developmental time from fixed Drosophila embryos using deep learning to study gene regulation dynamics without genetic modification.

Nature Communications · Jul 16, 2025Peer-reviewedBiophysics