J Costello

This study identifies genetic changes in IDH-mutant gliomas that correlate with treatment response and tumor evolution using longitudinal genomic data from 206 patient samples.

This study compares KalmanNet, an explainable BMI decoder, with deep-learning and Kalman filter models, finding it achieves comparable performance while offering interpretability.

The paper performs saturation mutagenesis on disease-associated regulatory elements to assess the functional effects of mutations, revealing variability in transcription factor binding site density and predictive power of conservation scores.