Author

M.C. Zhu

SLAC National Accelerator LaboratoryORCID 0000-0003-3268-0760Unclaimed ORCID profile · follow to get notified of new preprints

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

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Daniel HerschlagiD· 1 shared Elisa PieriiD· 1 shared Filip YabukarskiiD· 1 shared Jacob Parres-GoldiD· 1 shared Jason P. SchwansiD· 1 shared Margaux M. PinneyiD· 1 shared Rachael C. KretschiD· 1 shared Siyuan DuiD· 1 shared

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1 shared paperBiophysics

Daniel HerschlagORCID

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1 paper

Recent·Most cited

BiophysicsSciencePeer-reviewedFeb 13, 2025

Conformational Ensembles Reveal the Origins of Serine Protease Catalysis

Siyuan Du, Rachael C. Kretsch, Jacob Parres-Gold…·Daniel Herschlag

Ensemble-function analyses provide a quantitative model for serine protease catalysis, reveal previously unknown conformational features that contribute to their catalysis, and identify a structural motif that underlie these features and has evolved in >100 different enzymes from 32 protein folds.

65 citationstop 1%

protein structurestatistical model

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