Author

Margaux M. Pinney

QB3ORCID 0000-0002-7735-5032Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Duncan F. MuiriD· 3 shared Dylan Aidlen· 2 shared Garrison P. R. AsperiD· 2 shared Jacob A. PosneriD· 2 shared Nicholas Freitas· 2 shared Anna Kurianowicz· 1 shared Charles S. CraikiD· 1 shared Dashiell Anderson· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

Duncan F. MuirORCID

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Author profile →

3 papers

Recent·Most cited

Coupling high-throughput protease enzymology with viral replication reveals biochemical constraints of viral fitness

Dylan Aidlen, William Vinh Thanh Vo, Nicholas J. Young, Julia Rosecrans, Anna Kurianowicz, Shih‐Wei Chuo, Garrison P. R. Asper, Dashiell Anderson, Jacob A. Posner, Duncan F. Muir, Nicholas Freitas, Mélanie Ott, Charles S. Craik, Taha Y. Taha, Margaux M. Pinney

The paper links protease sequence variation to biochemical parameters and viral fitness using high-throughput enzymology and replication assays.

bioRxiv · Jan 28, 2026 · PreprintBiochemistry

Processing and Analyzing High-Throughput Microfluidic Enzymology Data: A Practical Guide To Rate Fitting and Quality Control

Nicholas Freitas, Jonathan S Zhang, Duncan F. Muir, Hayden S. Saunders, Dylan Aidlen, Margaux M. Pinney

The paper provides a guide for analyzing high-throughput microfluidic enzymology data, focusing on quality control and rate fitting using Michaelis-Menten kinetics.

Methods in enzymology on CD-ROM/Methods in enzymology · Jan 1, 2026Peer-reviewedBiochemistry

Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape

Duncan F. Muir, Garrison P. R. Asper, Pascal Notin, Jacob A. Posner, Debora S. Marks, Michael J. Keiser, Margaux M. Pinney

The paper measures catalytic constants for diverse Adenylate Kinase sequences and mutants, revealing distinct catalytic peaks and challenging existing hypotheses about thermophilic enzyme kinetics.

Science · Jun 12, 2025Peer-reviewedBiochemistry