Author

Leroy Bondhus

University of California, Los AngelesORCID 0000-0003-3398-5347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Valerie A. ArboledaiD· 3 shared Aileen A. NavaiD· 2 shared Angela WeiiD· 2 shared Benjamin A. GarciaiD· 1 shared Cameron J. Ong· 1 shared Celine K. VuongiD· 1 shared Connor T. JopsiD· 1 shared Dianne Gomez· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenomics

Valerie A. ArboledaORCID

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3 papers

Recent·Most cited

KAT6A mutations in Arboleda-Tham syndrome drive epigenetic regulation of posterior HOXC cluster

Meghna Singh, Sarah J. Spendlove, Angela Wei, Leroy Bondhus, Aileen A. Nava, Francisca N. de Luna Vitorino, Seth Amano, Jacob Lee, Gesenia Echeverria, Dianne Gomez, Benjamin A. Garcia, Valerie A. Arboleda

This study identifies KAT6A mutations in ARTHS patients and shows their role in epigenetic regulation of the posterior HOXC cluster through chromatin accessibility, histone acetylation, and DNA methylation changes.

Human Genetics · Oct 20, 2023Peer-reviewedGenomics

KAT6A mutations drive transcriptional dysregulation of cell cycle and Autism risk genes in an Arboleda-Tham Syndrome cerebral organoid model

Aileen A. Nava, Connor T. Jops, Celine K. Vuong, Samantha L. Niles-Jensen, Leroy Bondhus, Cameron J. Ong, Luis de la Torre-Ubieta, Michael J. Gandal, Valerie A. Arboleda

This study shows KAT6A mutations cause transcriptional dysregulation of cell cycle and autism risk genes in cerebral organoids, leading to delayed neural differentiation and altered gene expression patterns.

bioRxiv · Jun 17, 2023 · PreprintGenetics

DMRscaler: A Scale-Aware Method to Identify Regions of Differential DNA Methylation Spanning Basepair to Multi-Megabase Features

Leroy Bondhus, Angela Wei, Valerie A. Arboleda

DMRscaler identifies differential methylation regions across various epigenetic scales in DNA methylation data, outperforming existing methods in accuracy and range.

BMC Bioinformatics · Sep 5, 2022Peer-reviewedGenomics