Francisca N. de Luna Vitorino

This study expands the HIF-2α proteomic interactome using TurboID proximity labeling, identifying 329 novel interactors and linking some to poor patient survival in breast cancer.

The paper shows that cleavage of histone H2A by Cathepsin L during ESC differentiation reduces nucleosome stability and counteracts gene activation.

This study identifies ACSS2 as a mediator of prenatal alcohol exposure-related phenotypes, showing its role in histone acetylation and developmental changes in the brain.

The paper shows the ketogenic diet reduces excitatory synaptic gain by shrinking synaptic vesicle pools through transcriptional and epigenetic changes in the hippocampus.

This study shows DNASE1L3 clears surface DNA on B and T cells, and variants in DNASE1L3 are linked to higher surface DNA levels in autoimmune disease.

The paper introduces an unbiased proteomic platform for ATE1-based arginylation profiling, identifying 235 unique arginylation sites in human proteomes.

This study shows that inhibiting KAT6A/B with PF-9363 enhances retinoid efficacy and improves GD2-targeted immunotherapy in neuroblastoma.

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

This study shows that the EZH1Q571R mutation enhances chromatin compaction and PRC2 activity, leading to repression of tumor suppressor genes in follicular thyroid cancer.

In validated multicenter replications, 20 to 44% of 45 published Brazilian MTT, RT-PCR and elevated plus maze experiments replicated, depending on criterion; replication effects were usually smaller.

The paper systematically perturbs H3K36 methyltransferases in mouse mesenchymal stem cells to reveal their distinct roles in H3K36 methylation states and genomic distribution.

This study investigates how branched-chain amino acids (BCAAs) affect the proteomic profile of Pro-induced differentiation in Trypanosoma cruzi, revealing metabolic changes linked to reduced infectivity.

This study shows acetate improves spatial memory in female mice via sex- and brain region-specific epigenetic and transcriptional changes in the dorsal hippocampus.

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

This study identifies KAT6A mutations in ARTHS patients and shows their role in epigenetic regulation of the posterior HOXC cluster through chromatin accessibility, histone acetylation, and DNA methylation changes.

The paper profiles Y1 cells treated with FGF-2, revealing epigenetic and transcriptomic changes consistent with oncogene-induced senescence.