Author

David A. Liberles

Temple UniversityORCID 0000-0003-3487-8826Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:metabolomics· 1 Research Focus:phylogenetics / evolution· 1 Approach:simulation· 1 Research Focus:software / tool· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ayna MammedovaiD· 1 shared Nicholas S. McCloskey· 1 shared Ryan A Williams· 1 shared

Activity by Year

2024-2024 · peak 2/yr

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3 top collaborators · 1 mutual co-author link

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1 shared paperBioinformatics

Ayna MammedovaORCID

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2 papers

Recent·Most cited

BioinformaticsBMC BioinformaticsPeer-reviewedJul 18, 2024

PEMPS: A Phylogenetic Software Tool to Model the Evolution of Metabolic Pathways

Nicholas S. McCloskey, Ayna Mammedova, David A. Liberles

PEMPS simulates metabolic pathway evolution using mutation-selection models and phylogenetics to infer selection and ancestral states.

DOI 10.1186/s12859-024-05867-7

metabolomicsstatistical model

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJan 23, 2024

A Dynamic Programming Approach for the Alignment of Molecules

Ryan A Williams, David A. Liberles

This paper introduces a dynamic programming algorithm for aligning molecules in SMILES format to quantify structural transformations in metabolic pathways, showing a midpoint dissimilarity peak in cyclical pathways and progressive similarity decrease in linear pathways.

DOI 10.1101/2024.01.23.576849

statistical model

𝕏 PostBluesky