Systems BiologybioRxivPreprint
Commitment in the Pink1/Parkin mitophagy decision circuit
Christopher S Waters, Sigurd Angenent, Steven J. Altschuler, Lani F. Wu
The paper quantifies the relationship between PINK1 levels and Parkin recruitment dynamics to show a threshold and delay mechanism that prevents erroneous mitophagy activation.
DOI 10.1101/2022.10.07.510659