Author

Leslie Shing

MIT Lincoln LaboratoryORCID 0000-0003-3677-6698Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Emily Engelhart· 1 shared Esther Gupta· 1 shared John Spaeth· 1 shared Lin LiiD· 1 shared Matthew WalshiD· 1 shared Rafael JaimesiD· 1 shared Rajmonda S. CaceresiD· 1 shared Randolph M. Lopez· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBioinformatics

Emily Engelhart

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1 paper

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedJun 12, 2023

Machine Learning Optimization of Candidate Antibodies Yields Highly Diverse Sub-nanomolar Affinity Antibody Libraries

Lin Li, Esther Gupta, John Spaeth…·Matthew Walsh

This paper uses a Bayesian language model to design high-affinity scFv antibody libraries, achieving 28.8-fold better binding than directed evolution.

96 citationstop 1%

proteomicsBayesian inference

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