Molecular BiologyPLoS ONEPeer-reviewed
Differential laboratory passaging of SARS-CoV-2 viral stocks impacts the in vitro assessment of neutralizing antibodies
Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí…·Monica K. Borucki
The paper shows that passaging SARS-CoV-2 viral stocks under antiserum selection pressure increases genetic diversity and antibody escape mutations, making them more representative of circulating viruses.
DOI 10.1371/journal.pone.0289198