NeurosciencebioRxivPreprint
Familial Parkinson's Disease Mutations Converge on Alternative Splicing Programs Linked to Lysosomal, Autophagic and Vesicle Trafficking Pathways
Yeon J. Lee, Khaja Mohieddin Syed, Oriol Busquets…·Donald C. Rio
The paper investigates how familial Parkinson's disease mutations affect pre-mRNA splicing in dopaminergic neurons, identifying five functional classes of splicing changes and potential biomarkers and therapeutic targets.