GenomicsbioRxivPreprint
Pathway-scale variant effect mapping reveals the importance of cell context
Jessica J. Simon, Sriram Pendyala, A.Felicia Adebanjo…·Douglas M. Fowler
The paper measures variant effects across the MAPK pathway in human cells, revealing how cell context influences variant function and identifying 14,412 previously unknown dominant negative variants.
DOI 10.64898/2026.10.04.756099