ZIKA virus effects on neuroprogenitors are exacerbated by the main pyriproxyfen metabolite via thyroid hormone signaling disruption
Petra Špirhanzlová, Anthony Sébillot, Pieter Vancamp, Jean‐David M. Gothié, Sébastien Le Mével, Michelle Leemans, Karn Wejaphikul, Marcel E. Meima, Bilal B. Mughal, Lucile Butruille, Pierre Roques, Sylvie Remaud, Jean‐Baptiste Fini, BARBARA A. DEMENEIX
This study shows that the pesticide metabolite 4-OH-PPF worsens ZIKV effects on neuroprogenitors by disrupting thyroid hormone signaling, increasing MSI1 expression, and altering gene expression related to brain development.
bioRxiv · Nov 3, 2020 · PreprintNeuroscience