Author

Joshua R. Sacher

Broad InstituteORCID 0000-0003-4381-3979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Albert J. KooistraiD· 1 shared Allan Grønlund· 1 shared Allison T. HandsiD· 1 shared Amos GutnickiD· 1 shared Anders Dyhr Norlov· 1 shared Andrew S. BoghossianiD· 1 shared Ann DevineiD· 1 shared Anne Elizabeth CarpenteriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Albert J. KooistraORCID

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2 papers

Recent·Most cited

BiophysicsJournal of Chemical Information and ModelingPeer-reviewedAug 18, 2026

Unlocking Scalable Ligand Residence Time Predictions with Koffee Unbinding Kinetics Simulations

Niels Kristian Madsen, Robert M. Ziolek, Daniel Kongsgaard…·Nikolaj Thomas Zinner

This paper introduces Koffee Unbinding Kinetics, a method for fast, scalable prediction of ligand-protein residence times to improve drug discovery.

DOI 10.1021/acs.jcim.6c01781

deep learningstatistical model

𝕏 PostBluesky

BioinformaticsCell SystemsPeer-reviewedSep 1, 2022

Virtual screening for small molecule pathway regulators by image profile matching

Mohammad Hossein Rohban, Ashley M. Fuller, Ceryl Tan…·Anne Elizabeth Carpenter

The paper identifies small molecule regulators of biological pathways by matching compound effects to known pathway phenotypes in public cell image data.

36 citationstop 5%

𝕏 PostBluesky