NeuroscienceTranslational PsychiatryPeer-reviewed
Meta-analysis of Reward Processing in Major Depressive Disorder Reveals Distinct Abnormalities within the Reward Circuit
Tommy H. Ng, Lauren B. Alloy, David Victor Smith
This study performs a meta-analysis of neuroimaging data to show that major depressive disorder is associated with opposing abnormalities in the reward circuit, including hypo-responses in the ventral striatum and hyper-responses in the orbitofrontal cortex.