Xiao-Pan Hu

The paper shows that 49% of bacterial gene families are preferentially located near the origin or terminus of replication, supporting growth rate-dependent expression optimization.

The paper analyzes proteome efficiency across metabolic pathways in E. coli, finding that efficiency increases along the nutrient flow, with costly pathways near optimal and transporters and central metabolism over-abundant.

This paper introduces TurNuP, a model predicting enzyme turnover numbers for natural reactions, outperforming existing methods and generalizing across enzyme similarity.

The paper investigates the spatial organization of bacterial transcriptional regulatory networks using chromatin interaction data from E. coli and B. subtilis, revealing stable spatial features under different conditions.

The paper derives an optimal growth law for RNA composition in bacteria and shows that tRNA/rRNA ratio declines with growth rate, partially regulated by gene location.