IgG4⁺ plasma cell enrichment and {lambda}-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary disease
Luo Duan, Hongyun Zhao, Yanqi Xia…·Ying Sun
This study identifies IgG4⁺ plasma cell enrichment and λ-chain-biased BCR remodeling in COPD, linking them to low-grade autoimmunity and chronic inflammation.