Hongyun Zhao

This paper reports the first complete de novo biosynthesis of four bioactive Paris saponins in yeast by engineering sugar donor specificity and integrating biosynthetic modules.

This study identifies IgG4⁺ plasma cell enrichment and λ-chain-biased BCR remodeling in COPD, linking them to low-grade autoimmunity and chronic inflammation.

This study identifies CWF19L2 as a critical regulator of pre-mRNA alternative splicing during the maternal-to-zygotic transition, showing its necessity for female fertility.

This study identifies ZCWPW2 as a dual histone methylation reader that links H3K4me3 and H3K36me3 to meiotic DSB formation by interacting with key recombination proteins.

This study identifies Ribophorin-1 as a host factor that reduces spike protein abundance on coronaviruses by promoting its degradation, thereby inhibiting infection.

This study reveals how the Rpd3L complex uses an asymmetric architecture to activate deacetylation in response to chromatin context.

This paper develops CIRCMIP to profile intratumoral microbiota, identifies Staphylococcus lugdunensis as a bladder cancer biomarker, and reveals its metabolic role via LPC14:0-PPARδ signaling.