Author

Kevin C. Chan

The Ohio State UniversityORCID 0000-0003-4529-7904Unclaimed ORCID profile · follow to get notified of new preprints

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Approach:mixed model· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1

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Deliang GuoiD· 1 shared Xiaolin ChengiD· 1 shared Yan Yang· 1 shared Zoe Li· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperMolecular Biology

Deliang GuoORCID

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1 paper

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Molecular BiologybioRxivPreprintMay 29, 2025

Ammonia-mediated Conformational Dynamics in SCAP for SREBP Activation

Kevin C. Chan, Zoe Li, Yan Yang…·Xiaolin Cheng

This study uses molecular dynamics simulations to show ammonia induces conformational changes in SCAP that activate the SREBP pathway by promoting dissociation from Insig.

DOI 10.1101/2025.05.29.656818

protein structuremixed model

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