Primary Central Nervous System Lymphoma Tumor Biopsies Show Heterogeneity in Gene Expression Profiles, Genetic Subtypes, and in vitro Drug Sensitivity to Kinase Inhibitors
Yuan Xiao Zhu, Jasper Wong, Talal Hilal, Alanna Maguire, Jon Ocal, Katie R. Zellner, Xianfeng Chen, Brian K. Link, Thomas Matthew Habermann, Matthew John Maurer, James R. Cerhan, Patrick B. Johnston, Andrew L. Feldman, David W. Scott, Allison Claire Rosenthal, Lisa M. Rimsza
The paper identifies gene expression differences and genetic subtypes between PCNSL and DLBCL, and links CXCR4 mutations to ibrutinib resistance in PCNSL.
medRxiv · Nov 11, 2024 · PreprintGenetic & Genomic Medicine