David W. Scott

Single-cell spatial multi-omic characterization of the tumour microenvironment in transformed follicular lymphoma

The paper uses multi-omic single-cell spatial techniques to study FL transformation, finding spatial shifts in B-cell neighborhoods and immunomodulatory interactions linked to disease progression.

A patient derived xenograft repository capturing clinical and molecular heterogeneity of large B-cell lymphoma

The paper establishes a PDX repository of large B-cell lymphoma models capturing clinical and molecular diversity, including post-CART19 progression cases.

Spatial Proteomics Reveals Dual-Compartment Immune Evasion Architecture and Core Lymphomagenic Stromal Niches in Follicular Lymphoma

This study uses spatial proteomics to reveal immune evasion mechanisms in follicular lymphoma, identifying VISTA and CD14-high follicular dendritic cells as therapeutic targets.

The RNA helicase DDX21 cooperates with ETS1 and FLI1 in cell cycle, immune evasion, and snoRNA processing in activated B-cell-like diffuse large B-cell lymphoma cells

This study identifies DDX21 as a key effector of ETS1/FLI1 in ABC-DLBCL, linking it to cell cycle, immune evasion, and snoRNA processing, with potential therapeutic implications.

The Origin, Diagnosis, and Prognosis of Oligomannose-Type Diffuse Large B Cell Lymphoma

This paper identifies Mann-type DLBCL as a subtype of GCB-DLBCL characterized by oligomannose-type glycans in CDR-located AGS, associated with poor prognosis and distinct gene expression patterns.

Multidimensional characterization of cellular ecosystems in Hodgkin lymphoma

This study identifies four molecular subtypes of Hodgkin lymphoma using multimodal data, revealing distinct clinical features and immune ecosystem dynamics.

Primary Central Nervous System Lymphoma Tumor Biopsies Show Heterogeneity in Gene Expression Profiles, Genetic Subtypes, and in vitro Drug Sensitivity to Kinase Inhibitors

The paper identifies gene expression differences and genetic subtypes between PCNSL and DLBCL, and links CXCR4 mutations to ibrutinib resistance in PCNSL.

ESQmodel: biologically informed evaluation of 2-D cell segmentation quality in multiplexed tissue images

ESQmodel evaluates single-cell segmentation quality using expression data and a prior belief of cellular composition to compute per-cell entropy.

Integrated single cell analysis reveals co-evolution of malignant B cells and the tumor microenvironment in transformed follicular lymphoma

The paper uses single-cell sequencing to study the evolution of follicular lymphoma and its microenvironment during transformation, finding gene programs and TME changes associated with progression.

Robust gene expression-based classification of cancers without normalization

This paper introduces a self-training method for gene expression-based cancer classification that works across different data types and normalization methods.

Coding and regulatory drivers of mantle cell lymphoma identified through exome and genome sequencing

This study identifies genetic drivers of mantle cell lymphoma through exome and genome sequencing, revealing novel mutations in genes involved in RNA splicing and regulation.

Genome-wide discovery of somatic coding and regulatory variants in Diffuse Large B-cell Lymphoma

This study identifies somatic coding and regulatory variants in DLBCL, revealing novel mechanisms of oncogene deregulation and potential therapeutic targets.