Ligand promiscuity in the tryptophan repressor - from structural understanding towards rational design
André C. Stiel, S. Shanmugaratnam, Ole Herud-Sikimic, Gerd Jürgens, Birte Höcker
The paper investigates ligand promiscuity in the tryptophan repressor TrpR, elucidates structural and thermodynamic data, and demonstrates rational design of ligand specificity.
bioRxiv · Jan 20, 2020 · PreprintSynthetic Biology