Qing Feng Wu

This paper integrates Bayesian genome-wide polygenic scores into FRAX to improve fracture risk prediction in postmenopausal women, showing enhanced accuracy and reclassification.

This study uses single-cell RNA sequencing to analyze the expression of SPTBN1, EPDR1, and PKDCC across 15 human organ types, finding SPTBN1 is highly expressed in multiple tissues.

This study identifies three genes, EPDR1, PKDCC, and SPTBN1, with shared genetic architecture between muscle and bone, using GWAS data and functional mapping.

This study develops and validates genome-wide polygenic scores for bone mineral density and shows they improve fracture risk prediction when combined with clinical factors.