Kevin Chi Hao Ly

Tripso, a self-supervised transformer model, identifies gene program-specific embeddings and discovers novel gene programs, revealing biological insights in hematopoietic development and disease.

PerturbGen predicts how genetic perturbations affect cellular trajectories across time in human datasets, showing effects on immune responses, hematopoiesis, and skin development.

The paper uses division-resolved single-cell transcriptomics to study T cell activation and identifies gene programmes linked to immune disease by analyzing variant effects on cell division states.

The paper uses lineage recording techniques to study brain regionalization in cerebral organoids, finding that iPSC clones accumulate in distinct brain regions and lineage restriction increases over time.