Author

Thomas Walle

German Cancer Research CenterORCID 0000-0003-4835-955XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dana Pe’eriD· 2 shared Tal NawyiD· 2 shared Àlvaro Quintanal-VillalongaiD· 1 shared Andrea Littbarski· 1 shared Anja WilliamsiD· 1 shared Anmol AggarwaliD· 1 shared Anne-Katrin BergeriD· 1 shared Brigita MeškauskaitėiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Dana Pe’erORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 21, 2026

Hierarchical classification of immune cell transcriptomes at population-scale

Christopher Beltz, Zekai Qiu, Leon Sadowski…·Thomas Walle

The paper introduces Suco and Compocyte to classify immune cells from 3,965 patients, identifying new macrophage and monocyte states and T cell memory erosion in metastases.

DOI 10.64898/2026.05.30.728980

humanscRNA-seq

𝕏 PostBluesky

BioinformaticsNature BiotechnologyPeer-reviewedSep 21, 2023

Supervised discovery of interpretable gene programs from single-cell data

Russell Kunes, Thomas Walle, Max Land…·Dana Pe’er

This paper introduces Spectra, an algorithm that identifies and refines gene programs from single-cell data, outperforming existing methods in tumor immune contexts by improving interpretability and capturing cell-state changes.

96 citationstop 1%

humanscRNA-seq

𝕏 PostBluesky