BioinformaticsBioinformaticsPeer-reviewed
Non-negative Independent Factor Analysis disentangles discrete and continuous sources of variation in scRNA-seq data
Weiguang Mao, Maziyar Baran Pouyan, Dennis Kostka, Maria D. Chikina
The paper introduces NIFA, a probabilistic factor analysis model for scRNA-seq data that disentangles discrete cell-type identity and continuous pathway activity, outperforming existing methods in biological interpretation.