Robert S. Sade

This paper analyzes non-Arrhenius kinetics in a two-state folding system using a parabolic approximation model, showing how thermodynamic and entropic factors influence folding and unfolding rates.

The paper analyzes non-Arrhenius kinetics in a two-state folding system using a parabolic approximation model, revealing temperature-dependent stability and structural factors influencing folding behavior.

The paper develops a model using parabolic approximation to analyze two-state folding, determining equilibrium stability and rate constants through Gibbs energy functions of denatured and native states.