Systems BiologybioRxivPreprint
Genome-scale modeling reveals regulation of human metabolism by the histone deacetylase SIRT1
Jordi Roma Pi, Jean‐Marc Alberto, Justine Paoli…·Almut Heinken
The paper integrates SIRT1 transcriptional regulation into a genome-scale metabolic model to simulate host-microbiome interactions and metabolic responses to diet.
DOI 10.1101/2025.09.03.673976