BioinformaticsbioRxivPreprint
SPEAK: Spatial Prompting with Expert Aligned Knowledge for Tissue Domain Identification in Spatial Transcriptomics
Huanhuan Wei, Xiao Luo, Hongyi Yu…·Xiting Yan
SPEAK identifies spatial domains in spatial transcriptomics data using a large language model and expert-aligned prompts, showing improved accuracy and interpretability.
DOI 10.64898/2026.06.22.733750