Maor Sauler

SPEAK identifies spatial domains in spatial transcriptomics data using a large language model and expert-aligned prompts, showing improved accuracy and interpretability.

The paper investigates HHIP's role in epithelial wound healing and links its dysfunction to COPD susceptibility through computational modeling and experimental validation.

This study shows that Z-AAT expression in AT2 cells causes stress responses and increases emphysema risk in AATD.

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

This study uses scRNA-seq and scATAC-seq to show chronic cigarette smoke exposure enhances inflammatory and survival pathways in lung epithelial responses to influenza and hyperoxia.

The paper uses single-cell transcriptomics to analyze an IPF cohort, revealing a transcriptional deficit refractory to current treatments and identifying STAT3 as a key regulator in the therapeutic gap.

This paper introduces a tunable lung organoid model to study how cellular composition drives epithelial plasticity and immune polarization in chronic lung diseases.

This study shows NUPR1 inhibition worsens oxidative stress, mitochondrial dysfunction, and metabolic imbalance in COPD, linking it to ferroptosis and disease progression.

The paper identifies a nerve-fibroblast axis in lung fibrosis by integrating multiple experimental and computational approaches across species.

The paper identifies AGTR1 as a selective marker for lung pericytes and shows its role in regulating pericyte behaviors in the airspace microvasculature.

This paper introduces a statistical framework, cWAS, to identify cell types with genetically regulated proportions associated with complex diseases using integrated genetic and transcriptomics data.

A stabilized miR-29 mimic, MRG-229, shows efficacy at lower doses and good safety in preclinical models, supporting its development for pulmonary fibrosis.