Author

Puru Sharma

National University of SingaporeORCID 0009-0000-5854-1086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Assay:metagenomics· 1 Research Focus:sequence-to-function modeling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Limsoon WongiD· 2 shared Niranjan NagarajaniD· 2 shared Zhenhao GuiD· 2 shared Gary Yipeng Goh· 1 shared Hongyi XiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBioinformatics

Limsoon WongORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 4, 2026

Skiver: Reference-free quality control of metagenomic sequencing datasets using (k,v)-mer sketches

Zhenhao Gu, Puru Sharma, Limsoon Wong, Niranjan Nagarajan

Skiver estimates error rates and quality scores in metagenomic datasets using (k, v)-mer sketches without reference genomes or alignment.

DOI 10.64898/2026.02.12.705514

metagenomicsdeep learning

𝕏 PostBluesky

BioinformaticsiSciencePeer-reviewedOct 22, 2025

Efficient trace reconstruction in DNA storage systems using Bidirectional Beam Search

Zhiping Gu, Hongyi Xin, Puru Sharma…·Niranjan Nagarajan

This paper introduces Bidirectional Beam Search for efficient trace reconstruction in DNA storage systems, achieving high accuracy and speed on real datasets.

DOI 10.1016/j.isci.2025.113791

DNA methylationwhole-genome sequencing

𝕏 PostBluesky